Sunday, June 3, 2007

Regulatory regions in RNA: Splicing instruction in a mRNA


A mRNA may produce multiple proteins. Alternative splicing example is where splicing instruction is in the RNA itself (so the instruction isn't limited to DNA).
Example: doublesex (dsx) gene in Drosophila, which determines sex. dsx gene has 6 exons. A specific combination produces one sex. Females are made of exons 1, 2, 3, 4, while males 1,2,3,5,6.
This shows how a primary transcript can produce entirely different proteins through different ways of splicing mRNA, making unique combinations of exons, thus making unique proteins.
p.33 F2.11

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