Sunday, June 3, 2007

Irreversible modifications in DNA sequence: Antibody production


Antibody molecule, immunoglobin protein, is produced by a multi-step arrangement of the mRNA. For example: There are multiple V regions encoding for the variable region in a light chain. Each is labeled v1, v2, v3, etc.One of the V exons is attached to the J exon to make the final mRNA. The other V regions are lost, thus irreversible. The choosing of which v region is random. Final mRNA is perfected through further splicing.

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